Journal article
Antigenic Drift of the Pandemic 2009 A(H1N1) Influenza Virus in a Ferret Model
T Guarnaccia, LA Carolan, S Maurer-Stroh, RTC Lee, E Job, PC Reading, S Petrie, JM McCaw, J McVernon, AC Hurt, A Kelso, J Mosse, IG Barr, KL Laurie
Plos Pathogens | PUBLIC LIBRARY SCIENCE | Published : 2013
Abstract
Surveillance data indicate that most circulating A(H1N1)pdm09 influenza viruses have remained antigenically similar since they emerged in humans in 2009. However, antigenic drift is likely to occur in the future in response to increasing population immunity induced by infection or vaccination. In this study, sequential passaging of A(H1N1)pdm09 virus by contact transmission through two independent series of suboptimally vaccinated ferrets resulted in selection of variant viruses with an amino acid substitution (N156K, H1 numbering without signal peptide; N159K, H3 numbering without signal peptide; N173K, H1 numbering from first methionine) in a known antigenic site of the viral HA. The N156K..
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Funding Acknowledgements
The Melbourne WHO Collaborating Centre for Reference and Research on Influenza is supported by the Australian Government Department of Health and Ageing. J.M. McCaw is supported by an Australian Research Council Future Fellowship. T. Guarnaccia is the recipient of an Australian Postgraduate Award. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.The WHO Collaborating Centre for Reference and Research on Influenza has or has previously had collaborative agreements with the International Federation of Pharmaceutical and Manufacturers Associations, Novartis Vaccines & Diagnostics and CSL unrelated to this study. A. Kelso owns shares in CSL. J. McVernon has been a co-investigator on influenza vaccine studies sponsored by CSL, Sanofi and Novartis vaccines. She has received travel grants and honoraria from Novartis vaccines to support scientific presentations at meetings and conferences, and to sit on advisory boards. S. Maurer-Stroh, R.T.C. Lee, E. Job, S. Petrie, J.M. McCaw, and J. Mosse have no competing interests to declare. This does not alter our adherence to all PLoS Pathogens policies on sharing data and materials.